作者：Zhihua Cai, Guodu Liu, Guangjun Jiao, Chris H Senanayake, Wenjun Tang.*
关键字：N-Acetyl (E)-β-Arylenamides
论文来源：期刊
具体来源：Synthesis 2013, 45, 3355-3360. (DOI: 10.1055/s-0033-1339976, communication, IF = 2.867, Citation: 3)
发表时间：2013年

A facile and practical method for the preparation of (E)-β-arylenamides [(E)-N-(1-arylprop-1-en-2-yl]acetamides] has been developed by reductive acetylation of the corresponding oximes

with iron(II) acetate as the reducing reagent. Employment of hexamethylphosphoramide as the solvent was found to be critical for the high E/Z selectivity. The methodology has been applied in efficient syntheses of a key chiral intermediate of tamsulosin by asymmetric hydrogenation.